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Wertheim Leadership Lecture Series

Oct 4, 2021 Gut-Liver-Brain Axis in Chronic Multi-symptom Illnesses: Role of the Host Microbiome


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Full course description

Abstract: The last decade saw huge strides in understanding the significance of the host gut microbiome and its interaction with health and disease. The host microbiome has a symbiotic existence with the human microenvironment. Chatterjee's research has shown that chronic multisymptom illnesses arising from environment-immune dysbiosis, drug interactions, or liver immune dysregulations connect the gut microenvironment leading to neuroinflammation. The talk will address the specific role of gut bacterial and virome species, their metabolites in connecting to the enteric and central nervous system pathways, blood-brain-barrier leading glial cell activation.



Biography: Dr. Chatterjee is a human physiologist specializing in immunology.  He received his Ph.D. in inflammation biology (Life Science, Bhabha Atomic Research Center, U of Mumbai, India). After his postdoctoral work at the National Institute of Environmental Health Sciences, NIH, he specialized in chronic liver disease research at the Duke School of Medicine. His scientific contributions to redox biology, neuroimmune pathology, and gut-brain interaction in pro-inflammatory disease have significant implications to Gulf War illness, chronic multi-symptom illness, brain manifestations of liver diseases, drug discovery, and gut-brain directed therapeutics. Dr. Chatterjee is well-funded, with 80+ high-impact publications in gastroenterology, pharmacology, and toxicology.